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Relationship between hyperuricemia and metabolic syndrome*

Content Provider	PubMed Central
Author	Chen, Li-ying Zhu, Wen-hua Chen, Zhou-wen Dai, Hong-lei Ren, Jing-jing Chen, Jian-hua Chen, Lei-qian Fang, Li-zheng
Copyright Year	2007
Abstract	Objective: To investigate the relationship between metabolic syndrome and hyperuricemia. Methods: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as ≥7 mg/dl (in men) or ≥6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. Results: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia [odds ratio (OR)=1.634, P=0.000]. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. Conclusion: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome.
Related Links	http://dx.doi.org/10.1631/jzus.2007.B0593
Starting Page	593
File Format	PDF
ISSN	16731581
Journal	Journal of Zhejiang University. Science. B
Issue Number	8
Volume Number	8
Language	English
Publisher	Zhejiang University Press
Publisher Date	2007-08-01
Access Restriction	Open
Rights Holder	Zhejiang University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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