NDLI: Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome*

Content Provider	PubMed Central
Author	Tang, Li-jiang Jiang, Jian-jun Chen, Xiao-feng Wang, Jian-an Lin, Xian-fang Du, Yu-xi Fang, Cong-feng Pu, Zhao-xia
Abstract	Objective: Uric acid (UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome (MS). This study aims to investigate the relation between UA levels and aortic root dilatation. Methods: A total of 348 hypertensive patients [age (67.5±9.8) years] with or without MS were included in the study. The aortic root diameters at the aortic annulus, the sinuses of Valsalva, the sinotubular junction, and the proximal part of the ascending aorta were measured using a two-dimensional (2D) echocardiography. Serum UA levels were also measured for all patients. Results: A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva (P=0.001) and the proximal ascending aorta (P<0.0001) in the hypertensive patients without MS. In contrast, aortic root diameters were not significantly related to UA levels in the hypertensive patients with MS. Furthermore, increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS (sex-adjusted hazard ratio 1.75, 95% confidence intervals (CI) 1.27–2.41), but not in those with MS. Conclusions: This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without MS. Further understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.
Related Links	http://dx.doi.org/10.1631/jzus.b1001010
Ending Page	598
Page Count	7
Starting Page	592
File Format	PDF
ISSN	16731581
e-ISSN	18621783
Journal	Journal of Zhejiang University. Science. B
Issue Number	8
Volume Number	11
Language	English
Publisher	Zhejiang University Press
Publisher Date	2010-08-01
Access Restriction	Open
Rights Holder	Zhejiang University Press
Subject Keyword	Pharmacology, Toxicology and Pharmaceutics(all) Biochemistry, Genetics and Molecular Biology(all) veterinary(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Veterinary Medicine Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics

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