NDLI: Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.

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Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4.

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Role of the intergenic dinucleotide in vesicular stomatitis virus RNA transcription.

Antiviral immune responses in CTLA4 transgenic mice.

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Proteolytic processing of the coronavirus infectious bronchitis virus 1a polyprotein: identification of a 10-kilodalton polypeptide and determination of its cleavage sites.

Characterization of early stages in vaccinia virus membrane biogenesis: implications of the 21-kilodalton protein and a newly identified 15-kilodalton envelope protein.

Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1.

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Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products.

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Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239.

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Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin.

Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.

Distinct domains of adenovirus E1A interact with specific cellular factors to differentially modulate human immunodeficiency virus transcription.

CCAAT displacement protein, a regulator of differentiation-specific gene expression, binds a negative regulatory element within the 5' end of the human papillomavirus type 6 long control region.

Founder virus population related to route of virus transmission: a determinant of intrahost human immunodeficiency virus type 1 evolution?

Repression of host RNA polymerase II transcription by herpes simplex virus type 1.

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Position dependence of functional hairpins important for human immunodeficiency virus type 1 RNA encapsidation in vivo.

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Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis.

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In vitro selection of packaging sites in a double-stranded RNA virus.

Site-directed and linker insertion mutagenesis of herpes simplex virus type 1 glycoprotein H.

Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition.

Characterization of an ATPase activity in reovirus cores and its genetic association with core-shell protein lambda1.

Disassociation between the in vitro and in vivo effects of nitric oxide on a neurotropic murine coronavirus.

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Induction of cyclins E and A in response to mitogen removal: a basic alteration associated with the arrest of differentiation of C2 myoblasts transformed by simian virus 40 large T antigen.

Construction, replication, and immunogenic properties of a simian immunodeficiency virus expressing interleukin-2.

Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals.

Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles.

Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri.

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Generation of cytotoxic T lymphocytes against immunorecessive epitopes after multiple immunizations with adenovirus vectors is dependent on haplotype.

Glycoprotein H of herpes simplex virus type 1 requires glycoprotein L for transport to the surfaces of insect cells.

A multivalent minigene vaccine, containing B-cell, cytotoxic T-lymphocyte, and Th epitopes from several microbes, induces appropriate responses in vivo and confers protection against more than one pathogen.

Oral immunization with recombinant Mycobacterium bovis BCG simian immunodeficiency virus nef induces local and systemic cytotoxic T-lymphocyte responses in mice.

In vitro genetic selection analysis of alfalfa mosaic virus coat protein binding to 3'-terminal AUGC repeats in the viral RNAs.

Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant.

Assembly of African swine fever virus: role of polyprotein pp220.

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Mutational analysis of the oligomer assembly domain in the transmembrane subunit of the Rous sarcoma virus glycoprotein.

Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10.

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Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.

Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain.

The transneuronal spread phenotype of herpes simplex virus type 1 infection of the mouse hind footpad.

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Identification of the alpha6 integrin as a candidate receptor for papillomaviruses.

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Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective.

Phenotypically Vif- human immunodeficiency virus type 1 is produced by chronically infected restrictive cells.

Spontaneous establishment of an Epstein-Barr virus-infected fibroblast line from the synovial tissue of a rheumatoid arthritis patient.

Size variation within the second hypervariable region of the surface envelope gene of the bovine lentivirus BIV in experimentally and naturally infected cattle.

Utilization of nonhomologous minus-strand DNA transfer to generate recombinant retroviruses.

Molecular determinants for cellular uptake of Tat protein of human immunodeficiency virus type 1 in brain cells.

Structure-based rationale for the rescue of systemic movement of brome mosaic virus by spontaneous second-site mutations in the coat protein gene.

Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate.

Antibody-mediated neutralization of primary isolates of human immunodeficiency virus type 1 in peripheral blood mononuclear cells is not affected by the initial activation state of the cells.

Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene.

Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239.

Binding sites for adeno-associated virus Rep proteins within the human genome.

Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate.

Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2.

Reed-Sternberg cells and "bystander" lymphocytes in lymph nodes affected by Hodgkin's disease are infected with different strains of Epstein-Barr virus.

The herpesvirus saimiri ORF50 gene, encoding a transcriptional activator homologous to the Epstein-Barr virus R protein, is transcribed from two distinct promoters of different temporal phases.

Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo.

Mapping and characterization of the origin of DNA replication of porcine circovirus.

Suppression of apoptotic DNA fragmentation in herpes simplex virus type 1-infected cells.

Identification of nucleotide sequences that regulate transcription of the MCF13 murine leukemia virus long terminal repeat in activated T cells.

In vitro transcription of human T-cell leukemia virus type 1 is RNA polymerase II dependent.

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Double-stranded RNA is a trigger for apoptosis in vaccinia virus-infected cells.

Content Provider	PubMed Central
Author	Shors, T. Perkins, K. B. Zeman, C. C. Banaszak, M. P. Biesterfeldt, J. Langland, J. O. Jacobs, B. L. Kibler, K. V.
Abstract	The vaccinia virus E3L gene codes for double-stranded RNA (dsRNA) binding proteins which can prevent activation of the dsRNA-dependent, interferon-induced protein kinase PKR. Activated PKR has been shown to induce apoptosis in HeLa cells. HeLa cells infected with vaccinia virus with the E3L gene deleted have also been shown to undergo apoptosis, whereas HeLa cells infected with wild-type vaccinia virus do not. In this report, using virus recombinants expressing mutant E3L products or alternative dsRNA binding proteins, we show that suppression of induction of apoptosis correlates with functional binding of proteins to dsRNA. Infection of HeLa cells with ts23, which leads to synthesis of increased dsRNA at restrictive temperature, induced apoptosis at restrictive but not permissive temperatures. Treatment of cells with cytosine arabinoside, which blocks the late buildup of dsRNA in vaccinia virus-infected cells, prevented induction of apoptosis by vaccinia virus with E3L deleted. Cells transfected with dsRNA in the absence of virus infection also underwent apoptosis. These results suggest that dsRNA is a trigger that can initiate a suicide response in virus-infected and perhaps uninfected cells.
Starting Page	1992
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	3
Volume Number	71
Language	English
Publisher Date	1997-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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