NDLI: Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death.

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Mast cells in infection and immunity.

Low antigenicity of the polysaccharide region of Helicobacter pylori lipopolysaccharides derived from tumors of patients with gastric cancer.

Porphyromonas gingivalis lipopolysaccharide-stimulated bone resorption via CD14 is inhibited by broad-spectrum antibiotics.

Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1.

Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence.

A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence.

Characterization of two virulence proteins secreted by rabbit enteropathogenic Escherichia coli, EspA and EspB, whose maximal expression is sensitive to host body temperature.

Relevance of immunoglobulin G Fc receptor polymorphism to recurrence of adult periodontitis in Japanese patients.

Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro.

Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1.

Serum factors, cell membrane CD14, and beta2 integrins are not required for activation of bovine macrophages by lipopolysaccharide.

Evolutionary genetics of Pasteurella haemolytica isolates recovered from cattle and sheep.

Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells.

Comparison of the sequences and functions of Streptococcus equi M-like proteins SeM and SzPSe.

Analysis of expression of the alpha-toxin gene (hla) of Staphylococcus aureus by using a chromosomally encoded hla::lacZ gene fusion.

Necrosis versus apoptosis as the mechanism of target cell death induced by Entamoeba histolytica.

Role of adherence in interleukin-8 induction in Helicobacter pylori-associated gastritis.

Baculovirus-mediated expression of Plasmodium falciparum erythrocyte binding antigen 175 polypeptides and their recognition by human antibodies.

Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin.

Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages.

Specificity and functional activity of anti-Burkholderia pseudomallei polysaccharide antibodies.

The Oms66 (p66) protein is a Borrelia burgdorferi porin.

Vibrio mimicus attaches to the intestinal mucosa by outer membrane hemagglutinins specific to polypeptide moieties of glycoproteins.

Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella) catarrhalis.

Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death.

Analysis of the genes encoding the antigen 85 complex and MPT51 from Mycobacterium avium.

Virulence plasmid instability in Shigella flexneri 2a is induced by virulence gene expression.

Pathogenicity of three strains of Serpulina pilosicoli in pigs with a naturally acquired intestinal flora.

Outer membrane protein D15 is conserved among Haemophilus influenzae species and may represent a universal protective antigen against invasive disease.

Evidence for ethnic tropism of Helicobacter pylori.

Release of tumor necrosis factor alpha in response to Vibrio vulnificus capsular polysaccharide in in vivo and in vitro models.

Binding of Pasteurella haemolytica leukotoxin to bovine leukocytes.

SlyA, a transcriptional regulator of Salmonella typhimurium, is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages.

Role of interleukin 12 in experimental neonatal sepsis caused by group B streptococci.

A proposed role for the lutropin receptor in contact-inducible gonococcal invasion of Hec1B cells.

Identification of a Streptococcus gordonii SspB domain that mediates adhesion to Porphyromonas gingivalis.

Interaction of Mycobacterium avium with environmental amoebae enhances virulence.

Exposure to low oxygen tension and increased osmolarity enhance the ability of Mycobacterium avium to enter intestinal epithelial (HT-29) cells.

Effect of cytolethal distending toxin on F-actin assembly and cell division in Chinese hamster ovary cells.

Increased susceptibility of RAG-2 SCID mice to dissemination of endodontic infections.

Peyer's patch adherence of enteropathogenic Escherichia coli strains in rabbits.

Heterogeneity of antibodies reactive with the dominant antigen of Actinobacillus actinomycetemcomitans.

Shiga toxin-producing Escherichia coli isolates from cases of human disease show enhanced adherence to intestinal epithelial (Henle 407) cells.

The trypanocidal Cape buffalo serum protein is xanthine oxidase.

Streptococcus sanguis expresses a 150-kilodalton two-domain adhesin: characterization of several independent adhesin epitopes.

Mannan-specific immunoglobulin G antibodies in normal human serum mediate classical pathway initiation of C3 binding to Candida albicans.

Streptococcal mitogenic exotoxin Z, a novel acidic superantigenic toxin produced by a T1 strain of Streptococcus pyogenes.

Leukocytes in a Plasmodium falciparum-infected blood meal reduce transmission of malaria to Anopheles mosquitoes.

Mucoid Pseudomonas aeruginosa in cystic fibrosis: characterization of muc mutations in clinical isolates and analysis of clearance in a mouse model of respiratory infection.

Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality.

Evaluation of a bivalent (CVD 103-HgR/CVD 111) live oral cholera vaccine in adult volunteers from the United States and Peru.

Binding of vitronectin to opa-expressing Neisseria gonorrhoeae mediates invasion of HeLa cells.

Fimbriae and the hemagglutinating adhesin HA-Ag2 mediate adhesion of Porphyromonas gingivalis to epithelial cells.

Inhibition of nitric oxide interrupts the accumulation of CD8+ T cells surrounding Plasmodium berghei-infected hepatocytes.

Correlation of histopathologic and bacteriologic changes with cytokine expression in an experimental murine model of bacteremic Staphylococcus aureus infection.

Identification of phosphatidylinositol mannoside as a mycobacterial adhesin mediating both direct and opsonic binding to nonphagocytic mammalian cells.

Circulating promyelocytes and low levels of CD16 expression on polymorphonuclear leukocytes accompany early-onset periodontitis.

Molecular analysis of human cardiac myosin-cross-reactive B- and T-cell epitopes of the group A streptococcal M5 protein.

An Edwardsiella tarda strain containing a mutation in a gene with homology to shlB and hpmB is defective for entry into epithelial cells in culture.

In vitro inhibition of Cryptosporidium parvum infection by human monoclonal antibodies.

Allelic variation in Streptococcus pneumoniae autolysin (N-acetyl muramoyl-L-alanine amidase).

Use of cellular depletion analysis to examine circulation of immune effector function between the vagina and the periphery.

Giardia lamblia infections in B-cell-deficient transgenic mice.

Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice.

Neutrophils play a critical role in early resistance to amebic liver abscesses in severe combined immunodeficient mice.

Failure to detect binding of LcrH to the V antigen of Yersinia pestis.

A new restriction fragment length polymorphism from Cryptosporidium parvum identifies genetically heterogeneous parasite populations and genotypic changes following transmission from bovine to human hosts.

A nonsubstituted primary hydroxyl group in position 6' of free lipid A is required for binding of lipid A monoclonal antibodies.

A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis.

A putative leucine zipper activator of Pasteurella haemolytica leukotoxin transcription and the potential for modulation of its synthesis by slipped-strand mispairing.

Listeriolysin and IrpA are major protein targets of the human humoral response against Listeria monocytogenes.

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Coccoid forms of Helicobacter pylori are the morphologic manifestation of cell death.

Content Provider	PubMed Central
Author	Kusters, J. G. Gerrits, M. M. Van, Strijp J. A. Vandenbroucke-grauls, C. M.
Abstract	Helicobacter pylori can transform from its normal helical bacillary morphology to a coccoid morphology. Since this coccoid form cannot be cultured in vitro, it has been speculated that it is a dormant form potentially involved in the transmission of H. pylori and in a patient's relapse after antibiotic therapy. In this study we determined the effects of aging, temperature, aerobiosis, starvation, and antibiotics on the morphologic conversion rate and culturability of H. pylori. Aerobiosis and the addition of a bactericidal antibiotic to the culture medium resulted in the highest conversion rate. During the conversion to coccoid forms, the cultures always lost culturability at the stage where 50% of the organisms were still in bacillary form; this result indicated that culturability and coccoid morphology are two separate but related entities. Independent of the conditions used to induce the conversion into coccoids, the morphological conversion was accompanied by several marked antigenic and ultrastructural changes. Also, both the total amounts and the integrity of RNA and DNA were significantly reduced in coccoid forms. With the potential-sensitive probe diOC(5)-3, a clear loss of membrane potential in coccoid forms was observed. Inhibition of protein or RNA synthesis by the addition of bacteriostatic antibiotics did not prevent the conversion to coccoid forms but resulted in an increased conversion rate. Hence, we conclude that conversion of H. pylori from the bacillary to the coccoid form is a passive process that does not require protein synthesis. Our data suggest that the coccoid form of H. pylori is the morphologic manifestation of bacterial cell death.
Starting Page	3672
File Format	PDF
ISSN	10985522
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	9
Volume Number	65
Language	English
Publisher Date	1997-09-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

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