NDLI: Evidence for systemic rather than pulmonary effects ofinterleukin-5 administration in asthma

Content Provider	PubMed Central
Author	Rensen, E. L. J. Van Stirling, R. Scheerens, J. Staples, K. Sterk, P. Barnes, P. Chung, K.
Abstract	BACKGROUND—Interleukin5 (IL-5) has an important role in mobilisation of eosinophils from thebone marrow and in their subsequent terminal differentiation. A studywas undertaken to determine whether inhaled and intravenous IL-5 couldinduce pulmonary eosinophilia and bronchial hyperresponsiveness (BHR)independently of these effects. METHODS—Nine mildasthmatics received inhaled (15 µg) or intravenous (2 µg) IL-5 orplacebo in random order in a double blind, crossover study. Bloodsamples were taken before and at 0.5, 1, 2, 3, 4,5, 24, and 72 hoursfollowing IL-5 or placebo, and bronchial responsiveness (PC20 methacholine) and eosinophil counts in induced sputumwere determined. RESULTS—Serum IL-5levels were markedly increased 30 minutes after intravenous IL-5(p=0.002), and sputum IL-5 levels increased 4and 24 hours afterinhaled IL-5 (p<0.05). Serum eotaxin was raised 24 hours afterintravenous IL-5 but not after inhaled IL-5 or placebo. Bloodeosinophils were markedly reduced 0.5-2 hours after intravenous IL-5(p<0.05), followed by an increase at 3, 4, 5,and 72 hours (p<0.05).Sputum eosinophils rose significantly in all three groups at 24 hoursbut there were no differences between the groups. Bronchialresponsiveness was not affected by IL-5. CONCLUSION—The effectsof IL-5 appear to be mainly in the circulation, inducing peripheralmobilisation of eosinophils to the circulation without any effect oneosinophil mobilisation in the lungs or on bronchial responsiveness.
Related Links	http://dx.doi.org/10.1136/thorax.56.12.935
Starting Page	935
File Format	PDF
ISSN	14683296
e-ISSN	14683296
Journal	Thorax
Issue Number	12
Volume Number	56
Language	English
Publisher	BMJ Group
Publisher Date	2001-12-01
Access Restriction	Open
Rights Holder	BMJ Group
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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