NDLI: Response to influenza immunisation during treatment for cancer

Content Provider	PubMed Central
Author	Chisholm, J. Devine, T. Charlett, A. Pinkerton, C. Zambon, M.
Abstract	AIMS—To assess the annual risk ofinfluenza infection in children with cancer and the immunogenicity of atrivalent split virus influenza vaccine in these children. METHODS—Eighty four children withcancer were tested for susceptibility to the circulating strains ofinfluenza virus in autumn 1995and 1996. Non-immunised children werereassessed the following spring for serological evidence of naturalinfection. Forty two patients received two doses of influenza vaccine.These children were receiving continuing chemotherapy for acutelymphoblastic leukaemia or were within six months of completing chemotherapy. RESULTS—Among the 84 childrentested for influenza virus susceptibility only 8% of patients werefully protected (antibody titres ⩾ 40) against all three of theprevalent influenza virus strains; 33% were susceptible to all threeviruses. Evidence of acquired natural infection was seen in 30% ofunimmunised patients. Among immunised susceptible patients, 66% madesome protective response to the vaccine and 55% showed protectiveantibody titres to all three viral strains following vaccination. Olderage was associated with increased response to the H1N1 and H3N2 vaccinecomponents, but total white cell count or neutrophil count atimmunisation, type of cancer, or length of time on treatment for acutelymphoblastic leukaemia did not affect response. CONCLUSIONS—Most children withcancer studied were at risk of influenza infection. A significantresponse to immunisation was seen, supporting annual influenzavaccination for children being treated for cancer.
Related Links	http://dx.doi.org/10.1136/adc.84.6.496
Ending Page	500
Page Count	5
Starting Page	496
File Format	PDF
ISSN	00039888
e-ISSN	14682044
Journal	Archives of Disease in Childhood
Issue Number	6
Volume Number	84
Language	English
Publisher	BMJ Group
Publisher Date	2001-06-01
Access Restriction	Open
Rights Holder	BMJ Group
Subject Keyword	Obstetrics and Gynaecology Pediatrics, Perinatology, and Child Health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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