NDLI: Bone status in cystic fibrosis

Content Provider	PubMed Central
Author	Sood, M. Hambleton, G. Super, M. Fraser, W. Adams, J. Mughal, M.
Abstract	AIM—To investigate bone mineralstatus of children with cystic fibrosis (CF). METHODS—In 29 children with CF and49 matched controls, bone mineral content (BMC), projected bone area(BA), and areal bone mineral density (BMD) of the whole body, totalhip, and lumbar spine (L1-L4) were measured using dual energyx ray absorptiometry. The BMC values at eachsite were adjusted for BA, height, and weight. At the lumbar spine, thebone mineral apparent density (BMAD) was calculated by dividing the BMCby the estimated volume, derived from BA. Vertebral (T12-L3)trabecular bone mineral density (vTBMD) was measured using quantitativecomputed tomography in children with CF. Calcaneal broadband ultrasoundattenuation (BUA) was measured in CF patients and controls usingquantitative ultrasound. The disease severity of CF children wasevaluated by the Shwachman-Kulczycki (SK) score. RESULTS—The mean BUA, whole bodyand regional BA, adjusted BMC, and areal BMD of children with CF werenot different from those of controls. The mean BMAD of the lumbar spinewas reduced in CF patients compared with controls, whereas the meanvTBMD standard deviation scores were significantly higher in CFpatients. The median SK score of the CF group was 81 (range 42-100),indicating that as a group our CF patient population had relativelymild disease. CONCLUSION—The normal vertebralBMC, decreased BMAD, and higher vTBMD suggests that the vertebralcortical thickness or density might be reduced in CF subjects. Theoverall bone mineral status of CF children with relatively mild diseasewas not different from size matched controls.
Related Links	http://dx.doi.org/10.1136/adc.84.6.516
Ending Page	520
Page Count	5
Starting Page	516
File Format	PDF
ISSN	00039888
e-ISSN	14682044
Journal	Archives of Disease in Childhood
Issue Number	6
Volume Number	84
Language	English
Publisher	BMJ Group
Publisher Date	2001-06-01
Access Restriction	Open
Rights Holder	BMJ Group
Subject Keyword	Obstetrics and Gynaecology Pediatrics, Perinatology, and Child Health Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pediatrics, Perinatology and Child Health

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