NDLI: P2X receptor subtype-specific modulation of excitatory and inhibitory synaptic inputs in the rat brainstem

Content Provider	PubMed Central
Author	Watano, Tomokazu Calvert, Jennifer A. Vial, Catherine Forsythe, Ian D. Evans, Richard J.
Copyright Year	2004
Abstract	The role of P2 receptors in synaptic transmission to the rat medial nucleus of the trapezoid body (MNTB) was studied in an in vitro brain slice preparation. Whole-cell patch recordings were made and spontaneous synaptic responses studied under voltage clamp during application of P2X receptor agonists. ATPγS (100 μm) had no effect on holding current, but facilitated spontaneous excitatory postsynaptic current (sEPSC) frequency in 41% of recordings and facilitated spontaneous inhibitory postsynaptic currents (sIPSCs) in 20% of recordings. These were blocked by the P2 receptor antagonist suramin (100 μm). α,β-meATP also facilitated sEPSC and sIPSC frequency, while l-β,γ-meATP facilitated only sIPSCs. The sEPSC facilitation by ATPγS was blocked by TTX (but did not block facilitation of sIPSCs). sEPSC facilitation was blocked by PPADS (30 μm) and the selective P2X3 receptor antagonist A-317491 (3 μm), suggesting that modulation of sEPSCs involves P2X3 receptor subunits. α,β-meATP-facilitated sIPSCs were also recorded in wild-type mouse MNTB neurones, but were absent in the MNTB from P2X1 receptor-deficient mice demonstrating a functional role for P2X1 receptors in the CNS.
Related Links	http://dx.doi.org/10.1113/jphysiol.2004.066845
Ending Page	757
Page Count	13
Starting Page	745
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 3
Volume Number	558
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2004-08-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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