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| Content Provider | PubMed Central |
|---|---|
| Author | Shanker, Karunanithi Lavidis, Nickolas A. |
| Copyright Year | 2001 |
| Abstract | The effect of chronic morphine treatment (CMT) on sympathetic innervation of the mouse vas deferens and on α2-adrenoceptor mediated autoinhibition has been examined using intracellular recording of excitatory junction potentials (EJPs) and histochemistry. In chronically saline treated (CST) preparations, morphine (1 μM) and the α2-adrenoceptor agonist (clonidine, 1 μM) decreased the mean amplitude of EJPs evoked with 0.03 Hz stimulation by 81±8% (n=16) and 92±6% (n=7) respectively. In CMT preparations, morphine (1 μM) and clonidine (1 μM) decreased mean EJP amplitude by 68±8% (n=7) and 79±8% (n=7) respectively. When stimulating the sympathetic axons at 0.03 Hz, the mean EJP amplitude recorded from smooth muscles acutely withdrawn from CMT was four times greater than for CST smooth muscles (40.7±3.8 mV, n=7 compared with 9.9±0.3 mV, n=7). Part of the increase in mean EJP amplitude following CMT was produced by a 31% increase in the density of sympathetic axons and varicosities innervating the smooth muscle. Results from the present study indicate that the effectiveness of α2-adrenoceptor mediated autoinhibition is only slightly reduced in CMT preparations. Most of the cross tolerance which develops between morphine, clonidine and α2-adrenoceptor mediated autoinhibition occurs as a consequence of increased efficacy of neuromuscular transmission which is produced by an increase in the probability of transmitter release and an increase in the density of sympathetic innervation. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0703842 |
| Ending Page | 410 |
| Page Count | 8 |
| Starting Page | 403 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 2 |
| Volume Number | 132 |
| Language | English |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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