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| Content Provider | PubMed Central |
|---|---|
| Author | Choi, Se-young Kim, Yong-hyun Lee, Yong-kyu Kim, Kyong-tai |
| Copyright Year | 2001 |
| Abstract | The effect of chlorpromazine on the store-operated Ca2+ entry activated via the phospholipase C signalling pathway was investigated in PC12 cells. Chlorpromazine inhibited the sustained increase after the initial peak in the intracellular Ca2+ concentration produced by bradykinin while having no effect on the initial transient response. The inhibition was lowered by the removal of extracellular free Ca2+. However, chlorpromazine did not inhibit bradykinin-induced inositol 1,4,5-trisphosphate production. Chlorpromazine inhibited the bradykinin-induced noradrenaline secretion in a concentration-dependent manner (IC50: 24±5 μM, n=3). To test for a direct effect of chlorpromazine on store-operated Ca2+ entry, thapsigargin, an inhibitor of microsomal Ca2+-ATPase, was used to induce store-operated Ca2+ entry in PC12 cells. Chlorpromazine reduced the thapsigargin-induced sustained Ca2+ level (IC50: 24±2 μM, n=3), and the inhibition also occluded the inhibitory action of 1-[-[3-(4-methoxyphenyl) propoxy]-4-methoxyphenyl]-1H-imidazole hydrochloride (SK&F96365). The results suggest that chlorpromazine negatively modulates the store-operated Ca2+ entry activated subsequent to PLC activation. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0703840 |
| Ending Page | 418 |
| Page Count | 8 |
| Starting Page | 411 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 2 |
| Volume Number | 132 |
| Language | English |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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