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| Content Provider | PubMed Central |
|---|---|
| Author | Al-swayeh, O. A. Futter, L. E. Clifford, R. H. Moore, P. K. |
| Copyright Year | 2000 |
| Abstract | Nitroparacetamol (NCX-701) is a newly synthesized nitric oxide-releasing derivative of paracetamol. Following i.p. administration, nitroparacetamol inhibits carrageenan-induced hindpaw oedema formation (ED50, 169.4 μmol kg−1) and mechanical hyperalgesia (ED50, 156 μmol kg−1) in the rat. In contrast, the parent compound, paracetamol, exhibits no significant anti-oedema activity in this model (ED50>1986 μmol kg−1, i.p.) and is markedly less potent than nitroparacetamol as an inhibitor of carrageenan-mediated hyperalgesia (ED50, 411.6 μmol kg−1, i.p.). In a second model of nociception (inhibition of acetic acid induced abdominal constrictions in the mouse), nitroparacetamol administered orally (ED50, 24.8 μmol kg−1), was again considerably more potent than paracetamol (ED50, 506 μmol kg−1, p.o.). Thus, compared with paracetamol, nitroparacetamol not only exhibits augmented antinociceptive activity in both rat and mouse but, intriguingly, is also anti-inflammatory over a similar dose range. |
| Related Links | http://dx.doi.org/10.1038/sj.bjp.0703509 |
| Ending Page | 1456 |
| Page Count | 4 |
| Starting Page | 1453 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 7 |
| Volume Number | 130 |
| Language | English |
| Publisher Date | 2000-08-01 |
| Access Restriction | Open |
| Subject Keyword | Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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