NDLI: Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Content Provider	PubMed Central
Author	Dieter, Worlitzsch Tarran, Robert Ulrich, Martina Schwab, Ute Cekici, Aynur Meyer, Keith C. Birrer, Peter Bellon, Gabriel Berger, Jürgen Weiss, Tilo Botzenhart, Konrad Yankaskas, James R. Randell, Scott Boucher, Richard C. Döring, Gerd
Copyright Year	2002
Abstract	Current theories of CF pathogenesis predict different predisposing “local environmental” conditions and sites of bacterial infection within CF airways. Here we show that, in CF patients with established lung disease, Psuedomonas aeruginosa was located within hypoxic mucopurulent masses in airway lumens. In vitro studies revealed that CF-specific increases in epithelial O2 consumption, linked to increased airway surface liquid (ASL) volume absorption and mucus stasis, generated steep hypoxic gradients within thickened mucus on CF epithelial surfaces prior to infection. Motile P. aeruginosa deposited on CF airway surfaces penetrated into hypoxic mucus zones and responded to this environment with increased alginate production. With P. aeruginosa growth in oxygen restricted environments, local hypoxia was exacerbated and frank anaerobiosis, as detected in vivo, resulted. These studies indicate that novel therapies for CF include removal of hypoxic mucus plaques and antibiotics effective against P. aeruginosa adapted to anaerobic environments.
Related Links	http://dx.doi.org/10.1172/jci0213870
Ending Page	325
Page Count	9
Starting Page	317
File Format	PDF
ISSN	00219738
e-ISSN	15588238
Journal	The Journal of Clinical Investigation
Issue Number	3
Volume Number	109
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	2002-02-01
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus.

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis

Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?

Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients

Cross-infections with Pseudomonas aeruginosa in patients with cystic fibrosis attending the Warsaw Centre

Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis

Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Similar Documents

Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus.

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

Molecular Epidemiology of Chronic Pseudomonas aeruginosa Airway Infections in Cystic Fibrosis

Pulmonary bacteriophage and cystic fibrosis airway mucus: friends or foes?

Clinical outcomes associated with Staphylococcus aureus and Pseudomonas aeruginosa airway infections in adult cystic fibrosis patients

Cross-infections with Pseudomonas aeruginosa in patients with cystic fibrosis attending the Warsaw Centre

Synergistic airway gland mucus secretion in response to vasoactive intestinal peptide and carbachol is lost in cystic fibrosis

Recent advances in the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients