NDLI: Regulation of prostasin by aldosterone in the kidney

Content Provider	PubMed Central
Author	Narikiyo, Takefumi Kitamura, Kenichiro Adachi, Masataka Miyoshi, Taku Iwashita, Kozo Shiraishi, Naoki Hiroshi, Nonoguchi Chen, Li-mei Chai, Karl X. Chao, Julie Tomita, Kimio
Copyright Year	2002
Abstract	Prostasin is a serine protease present in mammalian urine that increases the activity of the epithelial sodium channel (ENaC) when the two are coexpressed in Xenopus oocytes. To determine if aldosterone, one of the principal regulators of urinary Na reabsorption by the distal nephron, affects prostasin expression, we examined prostasin mRNA and protein in a cultured mouse cortical collecting duct cell line (M-1), whole rats, and patients with primary aldosteronism. Aldosterone treatment of M-1 cells substantially increased prostasin expression and stimulated 22Na uptake. Urinary excretion of prostasin in rats that were infused with aldosterone likwise increased by ∼4-fold when compared with the vehicle-infused rats. Finally, urinary excretion of prostasin in patients with primary aldosteronism was substantially increased when compared with normal patients. Adrenalectomy reduced urinary prostasin excretion to control levels, whereas urinary prostasin levels were not altered in patients undergoing surgery for other reasons. In patients with primary aldosteronism, reduction in the urinary excretion of prostasin correlated with the increase in the urinary Na/K ratio. These findings, together with our previous report that prostasin activates the amiloride-sensitive Na currents through ENaC, demonstrate that prostasin regulates Na balance in vivo by virtue of its heightened expression in the presence of aldosterone.
Related Links	http://dx.doi.org/10.1172/jci0213229
Ending Page	408
Page Count	8
Starting Page	401
File Format	PDF
ISSN	00219738
e-ISSN	15588238
Journal	The Journal of Clinical Investigation
Issue Number	3
Volume Number	109
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	2002-02-01
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

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Regulation of Adrenal Aldosterone Production by Serine Protease Prostasin

EVIDENCE FOR SECRETION OF AN ALDOSTERONE-STIMULATING HORMONE BY THE KIDNEY *

Regulation of collecting tubule adenosine triphosphatases by aldosterone and potassium.

Role of aldosterone in the remnant kidney model in the rat.

The Regulation of Aldosterone Secretion in Anephric Man

Albuminuria is associated with an increased prostasin in urine while aldosterone has no direct effect on urine and kidney tissue abundance of prostasin

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Regulation by aldosterone of Na+,K+-ATPase mRNAs, protein synthesis, and sodium transport in cultured kidney cells

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Regulation of prostasin by aldosterone in the kidney

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Regulation of Adrenal Aldosterone Production by Serine Protease Prostasin

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Role of aldosterone in the remnant kidney model in the rat.

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