NDLI: Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential

Content Provider	PubMed Central
Author	Avraham, Dilmanian F. Zhong, Zhong Tigran, Bacarian Benveniste, Helene Romanelli, Pantaleo Wang, Ruiliang Jeremy, Welwart Yuasa, Tetsuya Rosen, Eliot M. Anschel, David J.
Copyright Year	2006
Abstract	Studies have shown that x-rays delivered as arrays of parallel microplanar beams (microbeams), 25- to 90-μm thick and spaced 100–300 μm on-center, respectively, spare normal tissues including the central nervous system (CNS) and preferentially damage tumors. However, such thin microbeams can only be produced by synchrotron sources and have other practical limitations to clinical implementation. To approach this problem, we first studied CNS tolerance to much thicker beams. Three of four rats whose spinal cords were exposed transaxially to four 400-Gy, 0.68-mm microbeams, spaced 4 mm, and all four rats irradiated to their brains with large, 170-Gy arrays of such beams spaced 1.36 mm, all observed for 7 months, showed no paralysis or behavioral changes. We then used an interlacing geometry in which two such arrays at a 90° angle produced the equivalent of a contiguous beam in the target volume only. By using this approach, we produced 90-, 120-, and 150-Gy 3.4 × 3.4 × 3.4 mm3 exposures in the rat brain. MRIs performed 6 months later revealed focal damage within the target volume at the 120- and 150-Gy doses but no apparent damage elsewhere at 120 Gy. Monte Carlo calculations indicated a 30-μm dose falloff (80–20%) at the edge of the target, which is much less than the 2- to 5-mm value for conventional radiotherapy and radiosurgery. These findings strongly suggest potential application of interlaced microbeams to treat tumors or to ablate nontumorous abnormalities with minimal damage to surrounding normal tissue.
Related Links	http://dx.doi.org/10.1073/pnas.0603567103
Ending Page	9714
Page Count	6
Starting Page	9709
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	103
Language	English
Publisher	National Academy of Sciences
Publisher Date	2006-06-20
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential.

Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.

Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.

Interlaced X-ray diffraction computed tomography

X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy

X-ray phase-contrast tomography with a compact laser-driven synchrotron source

Studies of dark energy with x-ray observatories

Motionless phase stepping in X-ray phase contrast imaging with a compact source

Radiation damage in protein crystals is reduced with a micron-sized X-ray beam

Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential

Similar Documents

Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential.

Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.

Subacute neuropathological effects of microplanar beams of x-rays from a synchrotron wiggler.

Interlaced X-ray diffraction computed tomography

X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy

X-ray phase-contrast tomography with a compact laser-driven synchrotron source

Studies of dark energy with x-ray observatories

Motionless phase stepping in X-ray phase contrast imaging with a compact source

Radiation damage in protein crystals is reduced with a micron-sized X-ray beam

Interlaced x-ray microplanar beams: A radiosurgery approach with clinical potential