NDLI: STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ

Content Provider	PubMed Central
Author	Xu, Min Nie, Lei Kim, Seung-hwan Sun, Xiao-hong
Copyright Year	2003
Abstract	Transcriptional activation is associated commonly with recruitment of histone acetylases, while repression involves histone deacetylases (HDACs). Here, we provide evidence to suggest that STAT5 activates gene expression by recruiting HDAC. The interleukin-3 (IL-3)-dependent expression of the Id-1 gene, encoding a helix–loop–helix (HLH) transcriptional inhibitor, is activated by both C/EBPβ and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE), but is inhibited by HDAC inhibitors in Ba/F3 cells. STAT5 interacts with HDAC1 in the PBE region, resulting in deacetylation of histones, as well as C/EBPβ, whose acetylation diminishes its DNA-binding activity. Consistently, expression of an acetylation-resistant mutant of C/EBPβ results in IL-3-independent expression of the Id-1 gene. Thus, we propose a novel mechanism by which STAT5 mediates the deacetylation of C/EBPβ, allowing transcriptional activation.
Related Links	http://dx.doi.org/10.1093/emboj/cdg094
Starting Page	893
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	4
Volume Number	22
Language	English
Publisher	Oxford University Press
Publisher Date	2003-02-17
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPβ