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| Content Provider | PubMed Central |
|---|---|
| Author | Kim, Kevin K. Flaherty, Kevin R. Long, Qi Hattori, Noboru Sisson, Thomas H. Travis, William D. Martinez, Fernando J. Murray, Susan Simon, Richard H. Colby, Thomas V. |
| Copyright Year | 2003 |
| Abstract | The normal fibrinolytic activity within the alveolar space is suppressed in fibrotic lung diseases in part because of increased levels of plasminogen activator inhibitor-1 (PAI-1). Studies with animals have shown that inhibition of the plasminogen system by PAI-1 increases the generation of pulmonary fibrosis. To determine if a similar relationship occurs in human fibrotic lung diseases, we took advantage of a polymorphism (4G/5G) that occurs in the promoter region of the human PAI-1 gene and influences the expression of PAI-1. We hypothesized that the 4G/4G genotype, because of its association with higher levels of PAI-1, would occur in patients with idiopathic interstitial pneumonia more frequently than in a control population. PAI-1 promoter genotype was determined in 88 well-characterized patients with idiopathic interstitial pneumonia consisting of 62 patients with usual interstitial pneumonia and 26 with nonspecific interstitial pneumonia. DNA was extracted from paraffin-embedded biopsy tissue and the genotype identified by polymerase chain reaction and restriction endonuclease digestion. We found that the distribution of PAI-1 genotypes in the idiopathic interstitial pneumonia population was similar to that of a large control population. However, subgroup analysis showed that patients with nonspecific interstitial pneumonia were more likely than the control population to have the promoter genotype (4G/4G) that is associated with higher levels of PAI-1. A similar pattern in PAI-1 polymorphism was not seen in the usual interstitial pneumonia subgroup. The results of this study support the conclusion that PAI-1 expression influences the development of nonspecific interstitial pneumonia in a similar manner to what occurs in animal models of pulmonary fibrosis. Patients with usual interstitial pneumonia did not show the same relationship with PAI-1 genotype. |
| Starting Page | 52 |
| File Format | |
| ISSN | 15283658 |
| e-ISSN | 15283658 |
| Journal | Molecular Medicine |
| Issue Number | 1-2 |
| Volume Number | 9 |
| Language | English |
| Publisher | ScholarOne |
| Publisher Date | 2003-01-01 |
| Access Restriction | Open |
| Rights Holder | ScholarOne |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Molecular Medicine Genetics (clinical) |
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