NDLI: Hypertension and Angiotensin II Hypersensitivity in Aminopeptidase A

Content Provider	PubMed Central
Author	Mitsui, Takashi Nomura, Seiji Okada, Mayumi Ohno, Yasumasa Kobayashi, Honami Nakashima, Yutaka Murata, Yasutaka Takeuchi, Mikihito Kuno, Naohiko Nagasaka, Tetsuo O-wang, Jiyang Cooper, Max D. Mizutani, Shigehiko
Copyright Year	2003
Abstract	Local concentrations of the vasopressor peptide, angiotensin II (AngII), depend upon the balance between synthesis and degradation. Previous studies of blood pressure (BP) regulation have focused primarily on the generation of AngII and its receptors, and less attention has been devoted to angiotensin degradation. Aminopeptidase A (APA, EC 3.4.11.7) is responsible for the N-terminal cleavage of AngII, a hydrolytic event that serves as a rate-limiting step in angiotensin degradation. To evaluate the physiological role of APA, we examined BP homeostasis in APA-deficient mice. We measured basal BP and BP with continuous infusion of AngII in APA mutant mice by tail-cuff method. We also evaluated the development and histology of AngII-targeted organs as well as urine excretion in these mice. Homozygous APA mutant mice were found to have elevated basal systolic BP when compared with heterozygous mutant and wild-type littermate mice. Infusion of AngII led to an enhanced systolic BP response in the APA-deficient mice. Despite the sustained elevation of BP in APA knockout mice, neither their renal and cardiac sizes nor their histological appearances were not different from control mice. Moreover, the volume, osmolality, and electrolyte content of the urine were normal in APA-deficient mice. APA deficiency increased baseline BP and enhanced the hypertensive response to increased levels of AngII. These findings indicate a physiological role for APA in lowering BP and offer novel insight into the mechanisms for developing hypertension.
Starting Page	57
File Format	PDF
ISSN	15283658
e-ISSN	15283658
Journal	Molecular Medicine
Issue Number	1-2
Volume Number	9
Language	English
Publisher	ScholarOne
Publisher Date	2003-01-01
Access Restriction	Open
Rights Holder	ScholarOne
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Molecular Biology Molecular Medicine Genetics (clinical)

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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