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| Content Provider | PubMed Central |
|---|---|
| Author | Nadin-davis, Susan A. Muldoon, Frances Wandeler, Alexander I. |
| Copyright Year | 2006 |
| Abstract | Genetic-variant analysis of rabies viruses provides the most sensitive epidemiologic tool for following the spread and persistence of these viruses in their wildlife hosts. Since its introduction by a southern epizootic movement that began in the far north, the arctic fox (AFX) strain of Rabies virus has been enzootic in Ontario for almost 50 y. Prior genetic studies identified 4 principal genetic variants (ONT.T1 to ONT.T4) that were localized to different regions of the province; furthermore, these viruses could be distinguished from the variant circulating in northern regions of Quebec, Newfoundland, and arctic zones, ARC.T5. Despite an intensive provincial control program undertaken over the last decade that involved aerial distribution of baits laden with rabies vaccine to combat fox rabies throughout the enzootic zone of Ontario, pockets of rabies activity persist. Re-evaluation of the genetic characteristics of the viral variants circulating in these areas of persistence has been undertaken. These data demonstrate that the recent outbreaks are, with 1 exception, due to persistence of the regional variant first identified in the area in the early 1990s. In contrast, the disease in the Georgian Bay area is a consequence of the incursion of a variant previously found further south. An outbreak that occurred in northern Ontario north and west of North Bay and in the neighboring border areas of Quebec in 2000–2001 was due to renewed incursion of the ARC.T5 variant from more northerly areas. |
| Starting Page | 11 |
| File Format | |
| ISSN | 08309000 |
| Journal | Canadian Journal of Veterinary Research |
| Issue Number | 1 |
| Volume Number | 70 |
| Language | English |
| Publisher | Canadian Veterinary Medical Association |
| Publisher Date | 2006-01-01 |
| Access Restriction | Open |
| Rights Holder | Canadian Veterinary Medical Association |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Medicine |
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