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| Content Provider | PubMed Central |
|---|---|
| Author | Baratin, Myriam Sophie, Roetynck Catherine, Lépolard Falk, Christine Sawadogo, Serge Uematsu, Satoshi Akira, Shizuo Ryffel, Bernhard Tiraby, Jean-gérard Alexopoulou, Lena Kirschning, Carsten J. Gysin, Jürg Vivier, Eric Ugolini, Sophie |
| Copyright Year | 2005 |
| Abstract | IFN-γ secretion by natural killer (NK) cells is pivotal to several tumor and viral immune responses, during which NK and dendritic cells cooperation is required. We show here that macrophages are mandatory for NK cell IFN-γ secretion in response to erythrocytes infected with Plasmodium falciparum (Pf), a causative agent of human malaria. In addition, direct sensing of Pf infection by NK cells induces their production of the proinflammatory chemokine CXCL8, without triggering their granule-mediated cytolytic programs. Despite their reported role in Pf recognition, Toll-like receptor (TLR) 2, TLR9, and TLR11 are individually dispensable for NK cell activation induced by Pf-infected erythrocytes. However, IL-18R expression on NK cells, IL-18 production by macrophages, and MyD88 on both cell types are essential components of this previously undescribed pathway of NK cell activation in response to a parasite infection. |
| Related Links | http://dx.doi.org/10.1073/pnas.0507355102 |
| Ending Page | 14752 |
| Page Count | 6 |
| Starting Page | 14747 |
| File Format | |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 41 |
| Volume Number | 102 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2005-10-11 |
| Access Restriction | Open |
| Rights Holder | National Academy of Sciences |
| Subject Keyword | General Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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