NDLI: G-protein gamma subunit 1 is required for sugar reception in Drosophila

Content Provider	PubMed Central
Author	Ishimoto, Hiroshi Takahashi, Kuniaki Ueda, Ryu Tanimura, Teiichi
Copyright Year	2005
Abstract	Though G-proteins have been implicated in the primary step of taste signal transduction, no direct demonstration has been done in insects. We show here that a G-protein gamma subunit, Gγ1, is required for the signal transduction of sugar taste reception in Drosophila. The Gγ1 gene is expressed mainly in one of the gustatory receptor neurons. Behavioral responses of the flies to sucrose were reduced by the targeted suppression of neural functions of Gγ1-expressing cells using neural modulator genes such as the modified Shaker K+ channel (EKO), the tetanus toxin light chain or the shibire (shi ts1 ) gene. RNA interference targeting to the Gγ1 gene reduced the amount of Gγ1 mRNA and suppressed electrophysiological response of the sugar receptor neuron. We also demonstrated that responses to sugars were lowered in Gγ1 null mutant, Gγ1 N159 . These results are consistent with the hypothesis that Gγ1 participates in the signal transduction of sugar taste reception.
Related Links	http://dx.doi.org/10.1038/sj.emboj.7600796
Ending Page	3265
Page Count	7
Starting Page	3259
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	18
Volume Number	24
Language	English
Publisher Date	2005-08-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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