NDLI: Telomere Variation in Xenopus laevis

Content Provider	PubMed Central
Author	Bassham, Susan Beam, Aaron Janis, Shampay
Copyright Year	1998
Abstract	Eukaryotic telomeres are variable at several levels, from the length of the simple sequence telomeric repeat tract in different cell types to the presence or number of telomere-adjacent DNA sequence elements in different strains or individuals. We have investigated the sequence organization of Xenopus laevis telomeres by use of the vertebrate telomeric repeat (TTAGGG) n and blot hybridization analysis. The (TTAGGG) n -hybridizing fragments, which ranged from less than 10 to over 50 kb with frequently cutting enzymes, defined a pattern that was polymorphic between individuals. BAL 31 exonuclease treatment confirmed that these fragments were telomeric. The polymorphic fragments analyzed did not hybridize to 5S RNA sequences, which are telomeric according to in situ hybridization. When telomeric fragments from offspring (whole embryos) were compared to those from the spleens of the parents, the inheritance pattern of some bands was found to be unusual. Furthermore, in one cross, the telomeres of the embryo were shorter than the telomeres of the parents’ spleen, and in another, the male’s testis telomeres were shorter than those of the male’s spleen. Our data are consistent with a model for chromosome behavior that involves a significant amount of DNA rearrangement at telomeres and suggest that length regulation of Xenopus telomeres is different from that observed for Mus spretus and human telomeres.
Starting Page	269
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	1
Volume Number	18
Language	English
Publisher	American Society for Microbiology
Publisher Date	1998-01-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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Fidelity of transcription of Xenopus laevis globin genes injected into Xenopus laevis oocytes and unfertilized eggs.

Molecular characterization of Xenopus laevis DP proteins.

Differential expression of the Xenopus laevis tadpole and adult beta-globin genes when injected into fertilized Xenopus laevis eggs.

Analysis of Histones in Xenopus laevis

Analysis of Histones in Xenopus laevis

Metaphase protein phosphorylation in Xenopus laevis eggs.

Developmentally regulated cytokeratin gene in Xenopus laevis.

E2F and its developmental regulation in Xenopus laevis.

Composite transposable elements in the Xenopus laevis genome.

Telomere Variation in Xenopus laevis

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Fidelity of transcription of Xenopus laevis globin genes injected into Xenopus laevis oocytes and unfertilized eggs.

Molecular characterization of Xenopus laevis DP proteins.

Differential expression of the Xenopus laevis tadpole and adult beta-globin genes when injected into fertilized Xenopus laevis eggs.

Analysis of Histones in Xenopus laevis

Analysis of Histones in Xenopus laevis

Metaphase protein phosphorylation in Xenopus laevis eggs.

Developmentally regulated cytokeratin gene in Xenopus laevis.

E2F and its developmental regulation in Xenopus laevis.

Composite transposable elements in the Xenopus laevis genome.

Telomere Variation in Xenopus laevis