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| Content Provider | PubMed Central |
|---|---|
| Author | Harvill, Eric T. Lee, Gloria Grippe, Vanessa K. Merkel, Tod J. |
| Copyright Year | 2005 |
| Abstract | Concerns regarding safety and control of virulent Bacillus anthracis have created substantial hurdles to the study of anthrax. The Sterne strain is considered relatively safe to study, but this acapsular strain has a defect in normal mice and is often studied in A/J mice. A/J mice are highly susceptible to the Sterne strain, due to a defect in the Hc locus, which encodes complement factor 5 (C5). Here we show that normally resistant C57BL/6 mice become highly susceptible to the Sterne strain upon complement depletion with cobra venom factor. This generalizable approach should allow the virulence of anthrax to be studied under relatively safe conditions and using a wide variety of mouse strains. |
| Related Links | http://dx.doi.org/10.1128/iai.73.7.4420-4422.2005 |
| Ending Page | 4422 |
| Page Count | 3 |
| Starting Page | 4420 |
| File Format | |
| ISSN | 00199567 |
| e-ISSN | 10985522 |
| Journal | Infection and Immunity |
| Issue Number | 7 |
| Volume Number | 73 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2005-07-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology Immunology Microbiology |
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