NDLI: Hepatocellular Tumor Induction in Heterozygous p53-Deficient CBA Mice by a 26-Week Dietary Administration of Kojic Acid

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Hepatocellular Tumor Induction in Heterozygous p53-Deficient CBA Mice by a 26-Week Dietary Administration of Kojic Acid

Content Provider	Paperity
Author	Hirose, Masao Tamura, Toru Mitsumori, Kunitoshi Nasu, Masahiro Takizawa, Tamotsu Imai, Toshio Ueda, Makoto
Abstract	In order to evaluate the tumorigenic potential of kojic acid (KA), used as a food additive for preventing enzymatic browning of crustaceans and a cosmetic agent for the purpose of skin whitening, heterozygous p53-deficient CBA [p53(+/âˆ’)] mice, which are recognized as useful for detecting genotoxic carcinogens, and wild-type littermates [p53(+/+) mice] were fed diet containing 0, 1.5, and 3% KA for 26 weeks. KA induced diffuse hypertrophy and hyperplasia of thyroid follicular epithelial cells with decreased serum thyroxine levels in both p53 (+/âˆ’) and p53 (+/+) mice, but caused no thyroid tumors. In the liver, the incidence of altered hepatocellular foci was significantly increased at 1.5 and 3% in p 53(+/âˆ’) and 1.5% in p53 (+/+) mice, and that of hepatocellular adenomas was increased at 1.5 and 3% in p 53(+/âˆ’) and 3% in p53 (+/+) mice. p53 (+/âˆ’) mice thus appeared to be more susceptible in terms of the tumorigenic dose of KA with a greater prevalence of hepatic proliferative lesions. The results of the present study indicate tumorigenic potential of KA in the liver, but not thyroid follicular epithelial cells in CBA mice and a contribution of genotoxicity on hepatocellular tumor development cannot be ruled out.
Starting Page	287
Ending Page	293
File Format	HTM / HTML
ISSN	10966080
DOI	10.1093/toxsci/kfg094
Issue Number	2
Journal	Toxicological Sciences
Volume Number	73
e-ISSN	10960929
Language	English
Publisher	Oxford University Press
Publisher Date	2003-06-01
Access Restriction	Open
Subject Keyword	Hepatocarcinogenesis Kojic acid
Content Type	Text
Resource Type	Article
Subject	Toxicology

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