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Reproductive factors and risks of biliary tract cancers and stones: a population-based study in Shanghai, China
| Content Provider | Paperity |
|---|---|
| Author | Zhang, B. -h Hou, L. Shen, M. -c Rashid, A. Brinton, L. A. Han, T. -q Andreotti, G. Sakoda, L. C. Chen, J. Hsing, A. W. Fraumeni Jr, J F Wang, B. -s Gao, Y. -t |
| Abstract | Background:Parity has been linked to gallbladder cancer and gallstones, but the effects of other reproductive factors are less clear.Methods:We examined 361 incident biliary tract cancer cases, 647 biliary stone cases, and 586 healthy women in a population-based study in Shanghai.Results:The effects of parity (odds ratios, OR3 vs 1 child=2.0, 95% confidence interval (CI) 0.7–5.1), younger age at first birth (ORper 1-year decrease=1.2, 95% CI 0.99–1.6), and older age at menarche (ORper 1-year increase=1.4, 95% CI 1.1–1.8) on gallbladder cancer risk were more pronounced among women with stones, but the interactions were not significant.Conclusion:Our results provide support for high parity, younger age at first birth, and late age at menarche in the development of gallbladder cancer, particularly among women with biliary stones. |
| Starting Page | 1185 |
| Ending Page | 1189 |
| File Format | HTM / HTML |
| ISSN | 15321827 |
| DOI | 10.1038/sj.bjc.6605597 |
| Journal | British Journal of Cancer |
| Volume Number | 102 |
| e-ISSN | 15321827 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2010-03-09 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
