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HEMODYNAMIC EFFECTS OF HIGH FREQUENCY OSCILLATORY VENTILATION (HFOV) PRETERM LAMBS
| Content Provider | Paperity |
|---|---|
| Author | Berry, David Ikegami, Machiko Jobe, Alan George, C. Emmanouilides Barry, G. Baylen Oguchi, Kouki Jacobs, Harris |
| Abstract | The effects of (HFOV) on the preterm cardiovascular system have not been evaluated. We studied 14 surfactant-treated preterm twin lambs (120 days gest. age) after occlusion of the ductus arteriosus with a balloon catheter. Left ventricular (LV) performance was evaluated using cineangiocardiography and radionuclide labeled microspheres. Studies were obtained after 2 and 3 hrs of conventional ventilation [CV] (Grp A, n=7) or HFOV (Grp B, n=7). HFOV was fixed at 15 Hz (900/min) and settings were adjusted to maintain similar blood gases in both groups. The following measurements were obtained: cardiac output (CO) ml min−1. kg−1, organ flows (% distribution,); LV ejection fraction (EF %), end diastolic volume (EDV); aortic:pulmonary mean (AO/PA) and mean airway pressures (MAP); ratio PaO2/FiO2.At similar end diastolic pressures and systemic resistances, and at comparable MAP and blood gases, there were no significant differences of LV performance or blood flow distribution with HFOV or CV (Wilcoxon test). Oxygenation (PaO2/FiO2) was similar in the groups. HFOV is an equally effective mode of ventilation and has no apparent deleterious effects upon the preterm cardiovascular system. |
| File Format | HTM / HTML |
| ISSN | 15300447 |
| DOI | 10.1203/00006450-198404001-01306 |
| Journal | Pediatric Research |
| e-ISSN | 15300447 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 1984-04-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
