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A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment
| Content Provider | Oxford Academic |
|---|---|
| Author | He, Mingwei Qin, Zainen Liang, Xiaonan He, Xixi Zhu, Bikang Lu, Zhenhui Wei, Qingjun Zheng, Li |
| Copyright Year | 2021 |
| Abstract | Andrographolide (AG) has favorable anti-inflammatory and antioxidative capacity. However, it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection, leading to low therapeutic efficiency in osteoarthritis (OA). Herein, we designed a nano-sized pH-responsive drug delivery system (DDS) for OA treatment by using modified mesoporous silica nanoparticles (MSNs) with pH-responsive polyacrylic acid (PAA) for loading of AG to form AG@MSNs-PAA nanoplatform. The nanoparticles have uniform size (∼120 nm), high drug loading efficiency (22.38 ± 0.71%) and pH-responsive properties, beneficial to sustained release in OA environment. Compared with AG, AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1β-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model, as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss. Therefore, the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS. |
| Related Links | https://academic.oup.com/rb/article-pdf/8/4/rbab020/38844749/rbab020.pdf |
| File Format | |
| ISSN | 20563418 |
| e-ISSN | 20563426 |
| DOI | 10.1093/rb/rbab020 |
| Journal | Regenerative Biomaterials |
| Issue Number | 4 |
| Volume Number | 8 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2021-06-21 |
| Access Restriction | Open |
| Subject Keyword | Materials Science Medicine and Health Science and Mathematics Chondrocytes Drug Delivery Systems Osteoarthritis Silicon Dioxide Nanoparticles Rats Mesoporous Silica Nanoparticles Polyacrylic Acid Ph-response Andrographolide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials |
