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pH-Sensitive Polyacrylic Acid-Gated Mesoporous Silica Nanocarrier Incorporated with Calcium Ions for Controlled Drug Release
| Content Provider | MDPI |
|---|---|
| Author | Kong, Jungwon Park, Sung Soo Ha, Chang-Sik |
| Copyright Year | 2022 |
| Description | In this work, polyacrylic acid-functionalized MCM-41 was synthesized, which was made to interact with calcium ions, in order to realize enhanced pH-responsive nanocarriers for sustained drug release. First, mesoporous silica nanoparticles (MSNs) were prepared by the sol-gel method. Afterward, a (3-trimethoxysilyl)propyl methacrylate (TMSPM) modified surface was prepared by using the post-grafting method, and then the polymerization of the acrylic acid was performed. After adding a calcium chloride solution, polyacrylic acid-functionalized MSNs with calcium-carboxyl ionic bonds in the polymeric layer, which can prevent the cargo from leaking out of the mesopore, were prepared. The structure and morphology of the modified nanoparticles (PAA-MSNs) were characterized by X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), and $N_{2}$ adsorption–desorption analysis, etc. The controlled release of guest molecules was studied by using 5-fluorouracil (5-FU). The drug molecule-incorporated nanoparticles showed different releasing rates under different pH conditions. It is considered that our current materials have the potential as pH-responsive nanocarriers in the field of medical treatment. |
| Starting Page | 5926 |
| e-ISSN | 19961944 |
| DOI | 10.3390/ma15175926 |
| Journal | Materials |
| Issue Number | 17 |
| Volume Number | 15 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-27 |
| Access Restriction | Open |
| Subject Keyword | Materials Mesoporous Silica Polyacrylic Acid Calcium Ion 5-fluorouracil Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
