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Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
| Content Provider | Oxford Academic |
|---|---|
| Author | Holbrook, Nolan R Klontz, Erik H Adams, Gordon C Schnittman, Samuel R Issa, Nicolas C Bond, Sheila A Branda, John A Lemieux, Jacob E |
| Copyright Year | 2023 |
| Abstract | We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4. The parasite was sequenced from an immunocompromised patient on prophylactic atovaquone for Pneumocystis pneumonia before diagnosis of babesiosis. |
| Related Links | https://academic.oup.com/ofid/article-pdf/10/3/ofad097/49601403/ofad097.pdf |
| File Format | |
| e-ISSN | 23288957 |
| DOI | 10.1093/ofid/ofad097 |
| Journal | Open Forum Infectious Diseases |
| Issue Number | 3 |
| Volume Number | 10 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2023-03-03 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Infectious Diseases Medicine and Health Babesia Microti Atovaquone Resistance Immunocompromised Babesiosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology Infectious Diseases |