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Severe Acute Respiratory Syndrome Coronavirus 2 Monoclonal Antibody Combination Therapy in Patients With Coronavirus Disease 2019 and Primary Antibody Deficiency
| Content Provider | Oxford Academic |
|---|---|
| Author | Pulvirenti, Federica Milito, Cinzia Cinetto, Francesco Fernandez Salinas, Ane Terreri, Sara Piano Mortari, Eva Auria, Stefania Soccodato, Valentina Miriam, Lichtner Nicastri, Emanuele Vincenzi, Laura Carsetti, Rita D’Offizi, Gianpiero Quinti, Isabella |
| Copyright Year | 2022 |
| Abstract | Background: Previous reports highlighted the efficacy of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific monoclonal antibodies (mAbs) against coronavirus disease 2019.MethodsWe conducted a prospective study on the clinical outcome and antiviral effects of mAbs added to standard of care therapy in SARS-CoV-2-infected patients with primary antibody defects.ResultsMedian time of SARS-CoV-2 quantitative polymerase chain reaction (qPCR) positivity was shorter in 8 patients treated with mAbs (22 days) than in 10 patients treated with standard of care therapy only (37 days, P=.026). Median time of SARS-CoV-2 qPCR positivity from mAb administration was 10 days.ConclusionsThe SARS-CoV-2 mAbs treatment was effective and well tolerated in patients with primary antibody defects. |
| Related Links | https://academic.oup.com/jid/article-pdf/225/5/820/42662138/jiab554.pdf |
| Ending Page | 824 |
| Starting Page | 820 |
| File Format | |
| ISSN | 00221899 |
| e-ISSN | 15376613 |
| DOI | 10.1093/infdis/jiab554 |
| Journal | The Journal of Infectious Diseases |
| Issue Number | 5 |
| Volume Number | 225 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2022-03-02 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Infectious Diseases Medicine and Health Coronavirus Monoclonal Antibodies Antibodies Common Variable Immunodeficiency Covid-19 Primary Antibody Deficiencies Sars-cov-2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy |
