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Direct Inject Mass Spectrometry for Illicit Chemistry Detection and Characterization
| Content Provider | University of North Texas |
|---|---|
| Author | Williams, Kristina Charlene |
| Description | The field of direct inject mass spectrometry includes a massive host of ambient ionization techniques that are especially useful for forensic analysts. Whether the sample is trace amounts of drugs or explosives or bulk amounts of synthetic drugs from a clandestine laboratory, the analysis of forensic evidence requires minimal sample preparation, evidence preservation, and high sensitivity. Direct inject mass spectrometry techniques can rarely provide all of these. Direct analyte-probed nanoextraction coupled to nanospray ionization mass spectrometry, however, is certainly capable of achieving these goals. As a multifaceted tool developed in the Verbeck laboratory, many forensic applications have since been investigated (trace drug and explosives analysis).Direct inject mass spectrometry can also be easily coupled to assays to obtain additional information about the analytes in question. By performing a parallel artificial membrane assay or a cell membrane stationary phase extraction prior to direct infusion of the sample, membrane permeability data and receptor activity data can be obtained in addition to the mass spectral data that was already being collected. This is particularly useful for characterizing illicit drugs and their analogues for a biologically relevant way to schedule new psychoactive substances. |
| File Format | |
| Archival Resource Key | ark:/67531/metadc849747 |
| Language | English |
| Publisher Date | 2019-04-04 |
| Publisher Place | Denton, Texas |
| Access Restriction | Open |
| Subject Keyword | Mass spectrometry forensic research direct analyte probed nanoextraction illicit drugs energetic materials parallel artificial membrane permeability assay cell membrane stationary phase Chemistry, Analytical |
| Content Type | Text |
| Resource Type | Thesis |
