Loading...
Please wait, while we are loading the content...
Similar Documents
Chikungunya and Zika Viruses: Co-Circulation and the Interplay between Viral Proteins and Host Factors
| Content Provider | MDPI |
|---|---|
| Author | Doroth, ée Missé Wichit, Sineewanlaya Gumpangseth, Nuttamonpat Hamel, Rodolphe Yainoy, Sakda Arikit, Siwaret Punsawad, Chuchard |
| Copyright Year | 2021 |
| Description | Chikungunya and Zika viruses, both transmitted by mosquito vectors, have globally re-emerged over for the last 60 years and resulted in crucial social and economic concerns. Presently, there is no specific antiviral agent or vaccine against these debilitating viruses. Understanding viral–host interactions is needed to develop targeted therapeutics. However, there is presently limited information in this area. In this review, we start with the updated virology and replication cycle of each virus. Transmission by similar mosquito vectors, frequent co-circulation, and occurrence of co-infection are summarized. Finally, the targeted host proteins/factors used by the viruses are discussed. There is an urgent need to better understand the virus–host interactions that will facilitate antiviral drug development and thus reduce the global burden of infections caused by arboviruses. |
| Starting Page | 448 |
| e-ISSN | 20760817 |
| DOI | 10.3390/pathogens10040448 |
| Journal | Pathogens |
| Issue Number | 4 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-09 |
| Access Restriction | Open |
| Subject Keyword | Pathogens Tropical Medicine Chikungunya Virus Zika Virus Antiviral Arbovirus Arbovirus–host Interactions |
| Content Type | Text |
| Resource Type | Article |
