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High Incidence of Zika or Chikungunya Infection among Pregnant Women Hospitalized Due to Obstetrical Complications in Northeastern Brazil—Implications for Laboratory Screening in Arbovirus Endemic Area
| Content Provider | MDPI |
|---|---|
| Author | Ana, Guimarães Rafael, França Jacques, Iracema Katz, Leila Sena, Marília Silva, Yasmim Albuquerque, Gabriela Pereira, Raisa de Albuquerque, Camila Silva, Maria Oliveira, Paula Albuquerque, Maria Cordeiro, Marli Marques, Ernesto Martelli, Celina Castanha, Priscila Braga, Cynthia |
| Copyright Year | 2021 |
| Description | The diagnostic of arbovirus-related obstetric complications in high-risk pregnancy and childbirth care is challenging, especially in endemic areas. We conducted a prospective study to track active or recent Zika (ZIKV), dengue (DENV), or chikungunya (CHIKV) virus infection among hospitalized pregnant women (PW) with obstetric complications in a hospital at the epicenter of Zika outbreak and ZIKV-related microcephaly in Brazil. Clinical data and blood samples were collected at enrollment and 10 days after the admission of study participants, between October 2018 and May 2019. Further clinical data were extracted from medical records. Samples were screened by molecular and serological tests. Out of 780 participants, 93.1% (95% CI: 91.1–94.7%) presented previous DENV exposure (IgG). ZIKV, CHIKV, and/or DENV laboratory markers of recent or active infection were detected in 130 PW, yielding a prevalence of 16.6% (95% CI: 14.2–19.5%); 9.4% (95% CI: 7.4–11.7%), 7.4% (95% CI: 5.7–9.7%), and 0.38% (95% CI: 0.1–1.2%) of CHIKV, ZIKV, and DENV infections, respectively. Most ZIKV infections were detected by molecular assays (89.6%), while CHIKV infections were detected by serology (95.9%). Our findings highlight the need for arbovirus infections screening in PW with obstetrical complications, potentially associated to these infections in endemic areas regardless of the signs or symptoms suggestive of arboviral disease. |
| Starting Page | 744 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v13050744 |
| Journal | Viruses |
| Issue Number | 5 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-23 |
| Access Restriction | Open |
| Subject Keyword | Viruses Tropical Medicine Zika Virus Dengue Virus Chikungunya Virus Pregnancy Complications |
| Content Type | Text |
| Resource Type | Article |
