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Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications
| Content Provider | MDPI |
|---|---|
| Author | Marina, Mühlberger Stein, René Friedrich, Bernhard Cebulla, Nadine Schreiber, Eveline Tietze, Rainer Cicha, Iwona Alexiou, Christoph Dutz, Silvio Boccaccini, Aldo R. Unterweger, Harald |
| Copyright Year | 2020 |
| Description | Surface-functionalized gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) may be a useful tool in various biomedical applications. To obtain Au-SPIONs, gold salt was precipitated onto citrate-stabilized SPIONs (Cit-SPIONs) using a simple, aqueous one-pot technique inspired by the Turkevich method of gold nanoparticle synthesis. By the further stabilization of the Au-SPION surface with additional citrate (Cit-Au-SPIONs), controllable and reproducible Z-averages enhanced long-term dispersion stability and moderate dispersion pH values were achieved. The citrate concentration of the reaction solution and the gold/iron ratio was found to have a major influence on the particle characteristics. While the gold-coating reduced the saturation magnetization to 40.7% in comparison to pure Cit-SPIONs, the superparamagnetic behavior of Cit-Au-SPIONs was maintained. The formation of nanosized gold on the SPION surface was confirmed by X-ray diffraction measurements. Cit-Au-SPION concentrations of up to 100 µg Fe/mL for 48 h had no cytotoxic effect on Jurkat cells. At a particle concentration of 100 µg Fe/mL, Jurkat cells were found to take up Cit-Au-SPIONs after 24 h of incubation. A significantly higher attachment of thiol-containing L-cysteine to the particle surface was observed for Cit-Au-SPIONs (53%) in comparison to pure Cit-SPIONs (7%). |
| Starting Page | 4425 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules25194425 |
| Journal | Molecules |
| Issue Number | 19 |
| Volume Number | 25 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-09-26 |
| Access Restriction | Open |
| Subject Keyword | Molecules Biomaterials Nanoparticles Superparamagnetic Iron Oxide Nanoparticles (spions) Gold Coating Thiol-binding Surface Functionalization Characterization Cytotoxicity |
| Content Type | Text |
| Resource Type | Article |
