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Advances in Lipid-Based Nanoparticles for Cancer Chemoimmunotherapy
| Content Provider | MDPI |
|---|---|
| Author | Wang, Tianqi Suita, Yusuke Miriyala, Saradha Dean, Jordan Tapinos, Nikos Shen, Jie |
| Copyright Year | 2021 |
| Description | Nanomedicines have shown great potential in cancer therapy; in particular, the combination of chemotherapy and immunotherapy (namely chemoimmunotherapy) that is revolutionizing cancer treatment. Currently, most nanomedicines for chemoimmunotherapy are still in preclinical and clinical trials. Lipid-based nanoparticles, the most widely used nanomedicine platform in cancer therapy, is a promising delivery platform for chemoimmunotherapy. In this review, we introduce the commonly used immunotherapy agents and discuss the opportunities for chemoimmunotherapy mediated by lipid-based nanoparticles. We summarize the clinical trials involving lipid-based nanoparticles for chemoimmunotherapy. We also highlight different chemoimmunotherapy strategies based on lipid-based nanoparticles such as liposomes, nanodiscs, and lipid-based hybrid nanoparticles in preclinical research. Finally, we discuss the challenges that have hindered the clinical translation of lipid-based nanoparticles for chemoimmunotherapy, and their future perspectives. |
| Starting Page | 520 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics13040520 |
| Journal | Pharmaceutics |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-09 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceutics Biomedical Engineering Chemoimmunotherapy Lipid-based Nanoparticles Liposomes Cancer Therapy Immunotherapy |
| Content Type | Text |
| Resource Type | Article |
