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Cationic Nanoparticle-Based Cancer Vaccines
| Content Provider | MDPI |
|---|---|
| Author | Heuts, Jeroen Jiskoot, Wim Ossendorp, Ferry van der Maaden, Koen |
| Copyright Year | 2021 |
| Description | Cationic nanoparticles have been shown to be surprisingly effective as cancer vaccine vehicles in preclinical and clinical studies. Cationic nanoparticles deliver tumor-associated antigens to dendritic cells and induce immune activation, resulting in strong antigen-specific cellular immune responses, as shown for a wide variety of vaccine candidates. In this review, we discuss the relation between the cationic nature of nanoparticles and the efficacy of cancer immunotherapy. Multiple types of lipid- and polymer-based cationic nanoparticulate cancer vaccines with various antigen types (e.g., mRNA, DNA, peptides and proteins) and adjuvants are described. Furthermore, we focus on the types of cationic nanoparticles used for T-cell induction, especially in the context of therapeutic cancer vaccination. We discuss different cationic nanoparticulate vaccines, molecular mechanisms of adjuvanticity and biodistribution profiles upon administration via different routes. Finally, we discuss the perspectives of cationic nanoparticulate vaccines for improving immunotherapy of cancer. |
| Starting Page | 596 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics13050596 |
| Journal | Pharmaceutics |
| Issue Number | 5 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-21 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceutics Biomedical Engineering Cancer Immunotherapy Vaccine Liposomes Nanoparticles Polymers |
| Content Type | Text |
| Resource Type | Article |
