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Baseline and Kinetic Circulating Tumor Cell Counts Are Prognostic Factors in a Prospective Study of Metastatic Colorectal Cancer
| Content Provider | MDPI |
|---|---|
| Author | Silva, Virgílio Abdallah, Emne Brito, Angelo Braun, Alexcia Tariki, Milena de Mello, Celso Calsavara, Vinicius Riechelmann, Rachel Chinen, Ludmilla |
| Copyright Year | 2021 |
| Description | The discovery of predictive biomarkers in metastatic colorectal cancer (mCRC) is essential to improve clinical outcomes. Recent data suggest a potential role of circulating tumor cells (CTCs) as prognostic indicators. We conducted a follow-on analysis from a prospective study of consecutive patients with mCRC. CTC analysis was conducted at two timepoints: baseline (CTC1; before starting chemotherapy), and two months after starting treatment (CTC2). CTC isolation/quantification were completed by ISET® (Rarecells, France). CTC expressions of drug resistance-associated proteins were evaluated. Progression-free survival (PFS) and overall survival (OS) were estimated by the Kaplan–Meier method. Seventy-five patients were enrolled from May 2012 to May 2014. A CTC1 cut-off of >1.5 CTCs/mL was associated with an inferior median OS compared to lower values. A difference of CTC2−CTC1 > 5.5 CTCs/mL was associated with a reduced median PFS. By multivariate analysis, CTC1 > 1.5 CTCs/mL was an independent prognostic factor for worse OS. Multi-drug resistance protein-1 (MRP-1) expression was associated with poor median OS. CTC baseline counts, kinetics, and MRP-1 expression were predictive of clinical outcomes. Larger studies are warranted to explore the potential clinical benefit of treating mCRC patients with targeted therapeutic regimens guided by CTC findings. |
| Starting Page | 502 |
| e-ISSN | 20754418 |
| DOI | 10.3390/diagnostics11030502 |
| Journal | Diagnostics |
| Issue Number | 3 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-12 |
| Access Restriction | Open |
| Subject Keyword | Diagnostics Oncology Circulating Tumor Cells Kinetics Metastatic Colorectal Cancer Prognosis Multidrug Resistance Protein 1 (mrp-1) |
| Content Type | Text |
| Resource Type | Article |
