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Clinical Relevance of Viable Circulating Tumor Cells in Patients with Metastatic Colorectal Cancer: The COLOSPOT Prospective Study
| Content Provider | MDPI |
|---|---|
| Author | Eric, François Jean-Pierre, Daurès Catherine, Alix-Panabières Mazard, Thibault Cayrefourcq, Laure Perriard, Françoise Senellart, Hélène Linot, Benjamin de la Fouchardière, Christelle Terrebonne, Eric Obled, Stéphane Guimbaud, Rosine Mineur, Laurent Fonck, Marianne Ychou, Marc Assenat, Eric |
| Copyright Year | 2021 |
| Description | Background: Circulating tumor cells (CTCs) allow the real-time monitoring of tumor course and treatment response. This prospective multicenter study evaluates and compares the early predictive value of CTC enumeration with EPISPOT, a functional assay that detects only viable CTCs, and with the $CellSearch^{®}$ system in patients with metastatic colorectal cancer (mCRC). Methods: Treatment-naive patients with mCRC and measurable disease (RECIST criteria 1.1) received FOLFIRI–bevacizumab until progression or unacceptable toxicity. CTCs in peripheral blood were enumerated at $D_{0}$, $D_{14}$, $D_{28}$, $D_{42}$, and $D_{56}$ (EPISPOT assay) and at $D_{0}$ and $D_{28}$ $(CellSearch^{®}$ system). Progression-free survival (PFS) and overall survival (OS) were assessed with the Kaplan–Meier method and log-rank test. Results: With the EPISPOT assay, at least 1 viable CTC was detected in 21% $(D_{0}$), 15% $(D_{14}$), 12% $(D_{28}$), 10% $(D_{42}$), and 12% $(D_{56}$) of 155 patients. PFS and OS were shorter in patients who remained positive, with viable CTCs between $D_{0}$ and $D_{28}$ compared with the other patients (PFS = 7.36 vs. 9.43 months, p = 0.0161 and OS = 25.99 vs. 13.83 months, p = 0.0178). The prognostic and predictive values of ≥3 CTCs $(CellSearch^{®}$ system) were confirmed. Conclusions: CTC detection at $D_{28}$ and the $D_{0}–D_{28}$ CTC dynamics evaluated with the EPISPOT assay were associated with outcomes and may predict response to treatment. |
| Starting Page | 2966 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13122966 |
| Journal | Cancers |
| Issue Number | 12 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-13 |
| Access Restriction | Open |
| Subject Keyword | Cancers Oncology Circulating Tumor Cells Colorectal Cancer Epispot Assay Cellsearch® System Predictive Value |
| Content Type | Text |
| Resource Type | Article |
