NDLI: Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)

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Rubella Seroprevalence Boost in the Pediatric and Adolescent Population of Florence (Italy) as a Preventive Strategy for Congenital Rubella Syndrome (CRS)

Content Provider	MDPI
Author	Zanella, Beatrice Boccalini, Sara Bonito, Benedetta Riccio, Marco Del Manzi, Federico Tiscione, Emilia Bonanni, Paolo Bechini, Angela
Copyright Year	2020
Description	Background: Despite the availability of an effective vaccine since the 1970s, rubella disease and, importantly, congenital rubella syndrome (CRS) remain a public health concern. The aim of this study was to analyze the rubella seroprevalence in the children population of the province of Florence and compare the obtained results to a previous survey conducted in 2005–2006. Methods: A qualitative measurement of anti-rubella antibodies was performed on 165 sera using the enzyme-linked immunosorbent Assay (ELISA). The anamnestic and vaccination status was also collected. Results: Our study highlighted a very high rubella seroprevalence (85–100%) in our enrolled population. In the vaccinated group (153/165), 98.7% of them were positive to rubella antibodies. Conclusions: Our study showed the highest seroprevalence rate reached in the province of Florence for rubella in the last 15 years, thanks to the several successful vaccination campaigns promoted in the Tuscany region. Our findings in pediatric and adolescent subjects are a key factor in preventing CRS in adult life, specifically in childbearing women. Thus, the set goal will be to keep the awareness about the vaccination for this preventable disease high.
Starting Page	599
e-ISSN	2076393X
DOI	10.3390/vaccines8040599
Journal	Vaccines
Issue Number	4
Volume Number	8
Language	English
Publisher	MDPI
Publisher Date	2020-10-12
Access Restriction	Open
Subject Keyword	Vaccines Womens Studies Rubella Crs Vaccination Coverage Pediatric Adolescent Seroprevalence Italy Florence Mmrv Vaccination Elimination
Content Type	Text
Resource Type	Article

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