NDLI: Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Compared to Xenogeneic or Synthetic Bone

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Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Compared to Xenogeneic or Synthetic Bone

Content Provider	MDPI
Author	Kim, Jooseong Kim, Sukyoung Song, Inhwan
Copyright Year	2021
Description	Octacalcium phosphate (OCP) is a precursor of biological apatite crystals that has attracted attention as a possible bone substitute. On the other hand, few studies have examined this material at the experimental level due to the limitations on OCP mass production. Recently, mass production technology of OCP was developed, and the launch of OCP bone substitutes is occurring. In this study, the bone regeneration capacity of OCP products was compared with two of the most clinically used materials: heat-treated bovine bone (BHA) and sintered biphasic calcium phosphate (BCP). Twelve rabbits were used, and defects in each tibia were filled with OCP, BHA, BCP, and left unfilled as control (CON). The tibias were harvested at 4 and 12 weeks, and 15 μm slides were prepared using the diamond grinding method after being embedded in resin. Histological and histomorphometric analyses were performed to evaluate the bone regeneration ability and mechanism. The OCP showed significantly higher resorption and new bone formation in both periods analysed (p < 0.05). Overall, OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralization), as well as providing additional space for new bone formation by rapid resorption.
Starting Page	5300
e-ISSN	19961944
DOI	10.3390/ma14185300
Journal	Materials
Issue Number	18
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2021-09-14
Access Restriction	Open
Subject Keyword	Materials Dentistry and Oral Surgery Octacalcium Phosphate (ocp) Hydroxyapatite (ha) Biphasic Calcium Phosphate (bcp) Xenogenic Bone Synthetic Bone Bone Regeneration Phase Conversion Mineralization
Content Type	Text
Resource Type	Article

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