NDLI: Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2

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Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2

Content Provider	MDPI
Author	Lim, Ho-Kyung Kwon, Ik-Jae Hong, Seok-Jin Yang, Byoung-Eun Kim, Soung-Min Lee, Jong-Ho Byun, Soo-Hwan
Copyright Year	2021
Description	Our aim was to investigate the bone regeneration capacity of powder-type biphasic ceramic scaffold (BCP powder), block-type BCP (BCP block), and collagen-added block-type BCP (BCP collagen) with different concentrations of recombinant human bone morphogenetic protein 2 (rhBMP-2) in an animal model. Four rabbits were assigned to each of the following groups: no graft + rhBMP-2 (0.1/0.2 mg/mL), BCP powder + rhBMP-2 (0.1/0.2 mg/mL), BCP block + rhBMP-2 (0.1/0.2 mg/mL), and BCP collagen + rhBMP-2 (0.1/0.2 mg/mL), i.e., a total of 32 rabbits. Polycarbonate tubes (Φ 7 mm × 5 mm) for supporting scaffolds were fixed into a 7 mm round border. Subsequently, 0.1 mL of rhBMP-2 solutions with different concentrations was injected into the tubes. Both radiological and histomorphometric analyses showed that osteogenesis was not enhanced by increasing the concentration of rhBMP-2 in all groups at both 3 and 6 weeks. Radiological analysis showed that bone formation was higher in the BCP collagen group than in the BCP powder and BCP block groups at both rhBMP-2 concentrations at 3 weeks. rhBMP-2 enhanced bone formation; however, as the concentration increased, bone formation could not be enhanced infinitely. Collagen-added alloplastic graft material may be useful for mediating rapid bone formation in initial stages.
Starting Page	11485
e-ISSN	14220067
DOI	10.3390/ijms222111485
Journal	International Journal of Molecular Sciences
Issue Number	21
Volume Number	22
Language	English
Publisher	MDPI
Publisher Date	2021-10-25
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Dentistry and Oral Surgery Biphasic Calcium Phosphate Block-type Biphasic Calcium Phosphate Scaffold Collagen Recombinant Human Bone Morphogenic Protein 2 Bone Regeneration
Content Type	Text
Resource Type	Article

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