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Heterogeneous Gold Nanoparticle-Based Catalysts for the Synthesis of Click-Derived Triazoles via the Azide-Alkyne Cycloaddition Reaction
| Content Provider | MDPI |
|---|---|
| Author | Francisco, J. Maldonado-Hódar Librando, Ivy L. Mahmoud, Abdallah G. Carabineiro, Sónia A. C. Silva, M. Fátima C. Guedes da Geraldes, Carlos F. G. C. Pombeiro, Armando J. L. |
| Copyright Year | 2021 |
| Description | A supported gold nanoparticle-catalyzed strategy has been utilized to promote a click chemistry reaction for the synthesis of 1,2,3-triazoles via the azide-alkyne cycloaddition (AAC) reaction. While the advent of effective non-copper catalysts (i.e., Ru, Ag, Ir) has demonstrated the catalysis of the AAC reaction, additional robust catalytic systems complementary to the copper catalyzed AAC remain in high demand. Herein, Au nanoparticles supported on $Al_{2}O_{3}$, $Fe_{2}O_{3}$, $TiO_{2}$ and ZnO, along with gold reference catalysts (gold on carbon and gold on titania supplied by the World Gold Council) were used as catalysts for the AAC reaction. The supported Au nanoparticles with metal loadings of 0.7–1.6% (w/w relative to support) were able to selectively obtain 1,4-disubstituted-1,2,3-triazoles in moderate yields up to 79% after 15 min, under microwave irradiation at 150 °C using a 0.5–1.0 mol% catalyst loading through a one-pot three-component (terminal alkyne, organohalide and sodium azide) procedure according to the “click” rules. Among the supported Au catalysts, $Au/TiO_{2}$ gave the best results. |
| Starting Page | 45 |
| e-ISSN | 20734344 |
| DOI | 10.3390/catal12010045 |
| Journal | Catalysts |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-31 |
| Access Restriction | Open |
| Subject Keyword | Catalysts Au Nanoparticles Supported Catalysts Azide-alkyne 1,2,3-triazoles |
| Content Type | Text |
| Resource Type | Article |
