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Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications
| Content Provider | MDPI |
|---|---|
| Author | Perrone, Daniela Marchesi, Elena Preti, Lorenzo Navacchia, Maria |
| Copyright Year | 2021 |
| Description | The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are known for their marked impact in cancer therapy and for the treatment of virus diseases and new targeted oligonucleotides have been developed for different purposes. The click chemistry allowing the tolerated union between units with a wide diversity of functional groups represents a robust means of designing new hybrid compounds with an extraordinary diversity of applications. This review provides an overview of the most recent works related to the use of click chemistry methodology in the field of nucleosides, nucleotides and nucleic acids for pharmacological applications. |
| Starting Page | 3100 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26113100 |
| Journal | Molecules |
| Issue Number | 11 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-05-22 |
| Access Restriction | Open |
| Subject Keyword | Molecules Organic Chemistry Click Chemistry 1,2,3-trizole Azide-alkyne Cycloaddition Bioisosteres Nucleosides Nucleic Acid Oligonucleotides Pharmaceutical Approach |
| Content Type | Text |
| Resource Type | Article |
