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Specialized Pro-Resolving Lipid Mediators: The Future of Chronic Pain Therapy?
| Content Provider | MDPI |
|---|---|
| Author | Mervin, Chávez-Castillo Valmore, Bermúdez Ortega, Ángel Cudris-Torres, Lorena Duran, Pablo Rojas, Milagros Manzano, Alexander Garrido, Bermary Salazar, Juan Silva, Aljadis Rojas-Gomez, Diana Marcela Sanctis, Juan B. De |
| Copyright Year | 2021 |
| Description | Chronic pain (CP) is a severe clinical entity with devastating physical and emotional consequences for patients, which can occur in a myriad of diseases. Often, conventional treatment approaches appear to be insufficient for its management. Moreover, considering the adverse effects of traditional analgesic treatments, specialized pro-resolving lipid mediators (SPMs) have emerged as a promising alternative for CP. These include various bioactive molecules such as resolvins, maresins, and protectins, derived from ω-3 polyunsaturated fatty acids (PUFAs); and lipoxins, produced from ω-6 PUFAs. Indeed, SPMs have been demonstrated to play a central role in the regulation and resolution of the inflammation associated with CP. Furthermore, these molecules can modulate neuroinflammation and thus inhibit central and peripheral sensitizations, as well as long-term potentiation, via immunomodulation and regulation of nociceptor activity and neuronal pathways. In this context, preclinical and clinical studies have evidenced that the use of SPMs is beneficial in CP-related disorders, including rheumatic diseases, migraine, neuropathies, and others. This review integrates current preclinical and clinical knowledge on the role of SPMs as a potential therapeutic tool for the management of patients with CP. |
| Starting Page | 10370 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms221910370 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 19 |
| Volume Number | 22 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-26 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Anesthesiology Chronic Pain Specialized Pro-resolving Lipid Mediators Inflammation Long-term Potentiation Central Nervous System Sensitization Polyunsaturated Fatty Acids Eicosanoids Nociception Omega 3 Fatty Acids Pain Management |
| Content Type | Text |
| Resource Type | Article |
