NDLI: Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases

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Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases

Content Provider	MDPI
Author	Gila-Diaz, Andrea Carrillo, Gloria Singh, Pratibha Ramiro-Cortijo, David
Copyright Year	2021
Description	Cardiovascular disease remains a leading cause of mortality worldwide. Unresolved inflammation plays a critical role in cardiovascular diseases development. Specialized Pro-Resolving Mediators (SPMs), derived from long chain polyunsaturated fatty acids (LCPUFAs), enhances the host defense, by resolving the inflammation and tissue repair. In addition, SPMs also have anti-inflammatory properties. These physiological effects depend on the availability of LCPUFAs precursors and cellular metabolic balance. Most of the studies have focused on the impact of SPMs in adult cardiovascular health and diseases. In this review, we discuss LCPUFAs metabolism, SPMs, and their potential effect on cardiovascular health and diseases primarily focusing in neonates. A better understanding of the role of these SPMs in cardiovascular health and diseases in neonates could lead to the development of novel therapeutic approaches in cardiovascular dysfunction.
Starting Page	933
e-ISSN	20763921
DOI	10.3390/antiox10060933
Journal	Antioxidants
Issue Number	6
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-06-08
Access Restriction	Open
Subject Keyword	Antioxidants Physiology Oxylipins Specialized Pro-resolving Mediators Long Chain Polyunsaturated Fatty Acids Newborn Premature Infant Cardiovascular Diseases
Content Type	Text
Resource Type	Article

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