NDLI: Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications

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Aspartic Acid Stabilized Iron Oxide Nanoparticles for Biomedical Applications

Content Provider	MDPI
Author	Mihaela, Răcuciu Olga, Drăghici Florin, Brînză Dorina, E. Creangă Barbu-Tudoran, Lucian Oancea, Simona Morosanu, Cezarina Grigoras, Marian
Copyright Year	2022
Description	Aspartic acid stabilized iron oxide nanoparticles (A-IONPs) with globular shape and narrow size distribution were prepared by the co-precipitation method in aqueous medium. A quantum-mechanical approach to aspartic acid optimized structure displayed negative charged sites, relatively high dipole moment, and hydrophilicity, which recommended it for interaction with iron cations and surrounding water electrical dipoles. A-IONPs were characterized by TEM, XRD, ATR-FTIR, EDS, DSC, TG, DLS, NTA, and VSM techniques. Theoretical study carried out by applying Hartree-Fock and density functional algorithms suggested that some aspartic acid properties related to the interaction can develop with nanoparticles and water molecules. The results of experimental investigation showed that the mean value of particle physical diameters was 9.17 ± 2.2 nm according to TEM image analysis, the crystallite size was about 8.9 nm according to XRD data, while the magnetic diameter was about 8.8 nm, as was determined from VSM data interpretation with Langevin’s theory. The A-IONP suspension was characterized by zeta-potential of about −11.7 mV, while the NTA investigation revealed a hydrodynamic diameter of 153.9 nm. These results recommend the A-IONP suspension for biomedical applications.
Starting Page	1151
e-ISSN	20794991
DOI	10.3390/nano12071151
Journal	Nanomaterials
Issue Number	7
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-03-30
Access Restriction	Open
Subject Keyword	Nanomaterials Iron Oxide Nanoparticles Nanoparticles Synthesis L-aspartic Acid Nanoparticles Size Physical and Chemical Characterization
Content Type	Text
Resource Type	Article

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