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Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum
| Content Provider | MDPI |
|---|---|
| Author | Liu, Ya-Ping Fang, Sheng-Tao Shi, Zhen-Zhen Wang, Bin-Gui Li, Xiao-Nian Ji, Nai-Yun |
| Copyright Year | 2020 |
| Description | Three new phenylhydrazones, penoxahydrazones A–C (compounds 1–3), and two new quinazolines, penoxazolones A (compound 4) and B (compound 5), with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep. Their structures and relative configurations were assigned by analysis of 1D/2D NMR and mass spectroscopic data, and the absolute configurations of 1, 4, and 5 were established on the basis of X-ray crystallography or ECD calculations. Compound 1 represents the first natural phenylhydrazone-bearing steroid, while compounds 2 and 3 are rarely occurring phenylhydrazone tautomers. Compounds 4 and 5 are enantiomers that feature quinazoline and cinnamic acid units. Some isolates exhibited inhibition of several marine phytoplankton species and marine-derived bacteria. |
| Starting Page | 9 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md19010009 |
| Journal | Marine drugs |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-12-28 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Medicinal Chemistry Organic Chemistry Penicillium Oxalicum Deep Sea Cold Seep Phenylhydrazone Quinazoline |
| Content Type | Text |
| Resource Type | Article |
