NDLI: Exercise versus Metformin to Improve Pregnancy Outcomes among Overweight Pregnant Women: A Systematic Review and Network Meta-Analysis

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Exercise versus Metformin to Improve Pregnancy Outcomes among Overweight Pregnant Women: A Systematic Review and Network Meta-Analysis

Content Provider	MDPI
Author	Celia, Álvarez-Bueno Gema, Sanabria-Martínez Raquel, Poyatos-León Beatriz, Rodríguez-Martín Vicente, Martínez-Vizcaíno Pascual-Morena, Carlos Cavero-Redondo, Iván Lucas-Torres, Maribel Lucerón-
Copyright Year	2021
Description	Being overweight is associated with pregnancy-related disorders such as gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), and excessive maternal weight gain (MWG). Exercise and metformin reduce the risk of these disorders. This network meta-analysis (NMA) aims to compare the effect of metformin and different types of exercise (aerobic, resistance and combined) on the risk of GDM, HDP, and MWG among overweight/obese pregnant women. Medline, EMBASE, Web of Science and Cochrane Library were searched from inception to June 2021. Meta-analyses and NMAs were performed. Sixteen randomized controlled trials were included. In the NMA, aerobic exercise showed an effect on GDM (RR = 0.51, 95% CI = 0.26, 0.97), and metformin a reduction in MWG (MWG = −2.93 kg, 95% CI = −4.98, −0.87). No intervention showed any effect on the reduction of HDP. Our study suggests that aerobic exercise may have the greatest effect in reducing the risk of GDM, and perhaps, the MWG. Strategies should be developed to increase adherence to this type of intervention among overweight women without contraindications. Although metformin could reduce MWG, medicalization of pregnancy in healthy women is not justified with the present results. More research is needed on the effect of the intensity and frequency of exercise sessions and the length of interventions.
Starting Page	3490
e-ISSN	20770383
DOI	10.3390/jcm10163490
Journal	Journal of clinical medicine
Issue Number	16
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2021-08-07
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Womens Studies Gestational Diabetes Mellitus Exercise Metformin Pregnancy Overweight Obesity Systematic Review Network Meta-analysis
Content Type	Text
Resource Type	Article

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