NDLI: The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

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The Effect of Dietary Supplements on Oxidative Stress in Pregnant Women with Gestational Diabetes Mellitus: A Network Meta-Analysis

Content Provider	MDPI
Author	Chatzakis, Christos Sotiriadis, Alexandros Tsakmaki, Evangelia Papagianni, Maria Paltoglou, George Dinas, Konstantinos Mastorakos, George
Copyright Year	2021
Description	Background: Gestational diabetes mellitus (GDM) exacerbates the oxidative stress status of the pregnant women. Τo improve the oxidative stress status, several therapeutic interventions have been suggested. The aim of this network meta-analysis is to assess the effect of different dietary supplements on the oxidative stress status in pregnant women with GDM. Methods: A network meta-analysis of randomized control trials was performed comparing the changes delta (Δ) in total antioxidant capacity (TAC) and concentration of malondialdehyde (MDA) as primary outcomes, following different therapeutic interventions with dietary supplements in pregnant women with GDM. Four electronic databases and grey literature sources were searched. The secondary outcomes were other markers of oxidative stress. Results: The meta-analysis included 16 studies of 1173 women with GDM. Regarding ΔTAC: probiotics and omega-3 with vitamin E were superior to placebo/no intervention. Regarding ΔMDA: vitamin D with calcium, omega-3, vitamin D, omega-3 with vitamin E, magnesium with zinc and calcium, and probiotics were superior to placebo/no intervention. Conclusions: Administration of dietary supplements in women with GDM can be helpful in limiting the oxidative stress which develop in these pregnancies.
Starting Page	2284
e-ISSN	20726643
DOI	10.3390/nu13072284
Journal	Nutrients
Issue Number	7
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-06-30
Access Restriction	Open
Subject Keyword	Nutrients Womens Studies Gestational Diabetes Mellitus Oxidative Stress Dietary Supplement Pregnancy Network Meta-analysis
Content Type	Text
Resource Type	Article

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