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Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update
| Content Provider | MDPI |
|---|---|
| Author | Giannoccaro, Maria Avoni, Patrizia Liguori, Rocco |
| Copyright Year | 2021 |
| Description | The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ. |
| Starting Page | 1035 |
| e-ISSN | 20763425 |
| DOI | 10.3390/brainsci11081035 |
| Journal | Brain Sciences |
| Issue Number | 8 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-03 |
| Access Restriction | Open |
| Subject Keyword | Brain Sciences Lambert Eaton Myasthenic Syndrome Neuromuscular Junction Presynaptic Disorders Paraneoplastic Syndrome Neuromyotonia Caspr2 Immune Checkpoint Inhibitors |
| Content Type | Text |
| Resource Type | Article |
