NDLI: Lambert-Eaton Myasthenic Syndrome

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Lambert-Eaton Myasthenic Syndrome

Content Provider	Scilit
Author	Kesner, Vita G. Oh, Shin J. Dimachkie, Mazen M. Barohn, Richard J.
Copyright Year	2018
Description	Journal: Neurologic Clinics Lambert-Eaton myasthenic syndrome is a paraneoplastic or primary autoimmune neuromuscular junction disorder characterized by proximal weakness, autonomic dysfunction and ariflexia. The characteristic symptoms are thought to be caused by antibodies generated against the P/Q-type voltage-gated calcium channels present on presynaptic nerve terminals and by diminished release of acetylcholine. More than half of Lambert-Eaton myasthenic syndrome cases are associated with small cell lung carcinoma. Diagnosis is confirmed by serologic testing and electrophysiologic studies. 3,4-diaminopyridine is effective symptomatic treatment of LEMS.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690495/pdf
Ending Page	394
Page Count	16
Starting Page	379
ISSN	07338619
e-ISSN	15579875
DOI	10.1016/j.ncl.2018.01.008
Journal	Neurologic Clinics
Issue Number	2
Volume Number	36
Language	English
Publisher	Elsevier BV
Publisher Date	2018-04-11
Access Restriction	Open
Subject Keyword	Journal: Neurologic Clinics Lambert-eaton Myasthenic Syndrome Neuromuscular Transmission Disorder Paraneoplastic Syndrome P/q-type Voltage-gated Calcium Channels 4-diaminopyridine
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)

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